genetics,lifestyle

Data miners have found a new vein of data, UK BioBank, in which 500,000 citizens have genetic information on them. I presented one of my studies on the effect of coffee and caffeine on my health and today’s research tries to put some light on the oldest problems, nature or nutrition.

The question raised was the lifestyle choices and the interaction of our genes; In view of cardiovascular disease and diabetes in this case. This study was confined to the Caucasian of British origin, whose entire genomic profile UK Biobank had captured a voluntary program, so it was difficult to normalize the results and findings. Polygenic patterns were identified for coronary artery disease, atrial fibrillation (an irregular heartbeat), stroke, high blood pressure and diabetes.

In these polygenic risk profiles, which contain different types of names, genes and single nucleotide collect polymorphisms, changes in a base pair are identified in the first scientific literature because the risks are linked to special results to form groups. As I mentioned earlier, they help in stratification, but generally “interpret” about 15% of cardiovascular disease, in this case, the incidence of cardiovascular disease or diabetes. Lifestyle was classified as compared to the American Heart Association guidelines for nutrition and exercise in the form of ideal, intermediate or poor.

[1] In this study 56, 9,000 participants watched, about 56 years, and a little more women than men. Ideal lifestyle in 20%, 5.2% poor, and the majority, as in the midst of the rest of us. Now, none of these patients were considered as health problems when the study started, and six years later, small percentages had new health problems, 4.8% had high blood pressure, 3.0% developed coronary artery disease, 2.1% developed Ariel Fibrillation, 0.9% stroke, and 1.6% diabetes.


There were more incidences of all targeted diseases in the higher genetic risk group. Intermediate risk and low-risk groups showed a slight difference in the frequency of the goal. So at least for the higher genetic risk profile, we identified the change in health outcomes.


Poor lifestyle has increased the risk of adverse consequences in each of the genetic risk groups. The worst results were those who were at the highest risk and the worst lifestyle. The ratio of risk, one way to explain increasing risk, increased fourfold for coronary artery disease and hypertension, and fewer genetic risks increased fifteen times for diabetes than the ideal lifestyle group.


Intermediate conclusions of people with genetic risks, and remember that the majority, you and me were the same as the low-risk genetic group. The most important effect was entirely due to poor lifestyle.
There were no significant additional differences on the basis of gender.

In short, researchers did not get any talks between genetic risk profile and lifestyle; the role of genes, at least on the basis of our current knowledge of genetic risk, contributed little to health consequences for cardiovascular disease and diabetes. The mistake does not seem to lie in our genes but our choices Hippocrates has been summed up with the thoughtful thought: “If we can give proper nutrition and exercise to every person, not very little and not much, then we will find the safest way to get healthy.”



You need 3 bad options to be poor lifestyle, e.g. At present, smoking, BMI> 30, not regular practice and less than half of the following: increase in the consumption of fruits, vegetables, whole grains, (shell) fish, dairy products and vegetable oils; And refined cereals, (combined) processed meat and sugar-sweet beverages, little or no consumption.

 

 

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