Diabetes can be dangerous and doctors suggest to treat the disease constantly to avoid several other complications. Researchers say that the increase in blood sugar levels tends to harm human DNA and elevate the risks of cancer. Controlling the blood sugar level is one way to reduce the risk of cancer. The urge of finding out the reasons behind the imposed risks of cancer in the patients suffering from type 1 and type 2 diabetes, took scientists to a breakthrough. They found that human DNA faces a lot of damage when a person suffers from high blood sugar level and takes a lot of time to repair from the damage caused due to high sugar levels. This increases the risks of cancer in a person’s body.
Risk Of Cancer
Ph.D. holder John Termini, who is representing the study at American Chemical Society Fall 2019 National Meeting said, “It’s been known for a long time that people with diabetes have as much as 2.5-fold increased risk for certain cancers.” The researchers also found that cancer risks in diabetic patients increase because of the hormonal imbalance. The list of cancer includes kidney, breast, ovarian, breast, and others. Termini also said that people who have Type 2 diabetes, their insulin levels are not effective enough to carry glucose into the cells, because of which the pancreas generate more insulin causing hyperinsulinemia. If we try controlling the blood glucose level by using insulin, it can increase the functionality of insulin leading to the growth of cancer.
Most of the people who suffer from Type 2 diabetes are overweight and because of their excessive fat tissues, they generate a high amount of adipokines which leads to chronic inflammation, giving rise to cancer. Termini, who works at the City of Hope, tried looking for the damages based on the chemically modified DNA called adducts. He and his colleagues found that the DNA adducts including, N2-(1-carboxyethyl)-2′-deoxyguanosine, or CEdG was present in a significant amount in those who had Type 2 diabetes. The scientists conclude that the high glucose levels in the blood increase DNA adducts and do not allow the cell to repair leading to cancer and instability of genome. By this research, the scientists wanted to look for the malfunction of cell repair mechanism on a molecular level, which answers their doubts that why the adducts were not fixing by the cells. The research showed that there were two proteins which were not functioning in diabetes and they were HIF1a and mTORC1. Now, the researchers are working on the drugs which can decrease the risk of cancer in diabetic patients. The trials are going on with diabetic animals and will be tested on humans later.